General Proximity pioneers next-generation medicines by controlling biological processes through proximity. Redefining the future of medicine for all humankind. Backed by Y Combinator and Felicis.
About the role
We are seeking an experienced mechanistic biologist to join our Discovery Biology Team. In this position, you will work closely with our Platform and Chemistry Teams to drive mechanistic understanding of our lead compounds and support core drug discovery efforts. This is an opportunity to help elucidate novel pharmacological mechanisms of our next-gen IPMs.
What they're looking for
- BS, MS or PhD in Cell Biology, Biochemistry, or related field
- Candidates without a PhD should have 5-7+ years of relevant industry experience
- Previous experience elucidating novel biology underlying small-molecule mechanism of action in a drug discovery context
- Top-notch written and oral communication skills
- Strong experience with :
- Small molecule drug development campaigns (hit discovery, hit validation, dose-response studies, SAR and MOA studies)
More about this role
General Proximity is a seed-stage startup developing the next generation of induced proximity medicines (IPMs). Our OmniTAC drug discovery engine furnishes molecules that co-opt existing cellular machinery to overcome therapeutic challenges, which have remained unapproachable to other modalities for decades.
We are seeking a first-rate mechanistic biologist to help us pioneer this uncharted frontier of drug discovery.
A long-standing challenge in drug discovery is the development of molecules capable of modulating difficult or "undruggable" targets. Disease-causing proteins can be dysfunctional in many different ways, but our armamentarium for fixing them is quite limited. The most common mechanism of action for FDA-approved drugs is inhibition [1] , but there are many other possible perturbation types whose potential remains unrealized.
General Proximity is a seed-stage drug discovery company developing a novel platform technology to solve this problem. We make bifunctional drugs that induce the modification of drug targets by existing cellular machinery (rather than through direct modulation by the drug, the classical approach).
Historically, the development of technologies that...
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