General Proximity pioneers next-generation medicines by controlling biological processes through proximity. Redefining the future of medicine for all humankind. Backed by Y Combinator and Felicis.
About the role
We are seeking a medicinal chemist to be a member of our Chemistry/Drug Discovery Team. In this position, you will work with both our Chemistry and Platform Teams in the development of our core drug discovery technology and the generation of a completely novel class of therapeutics.
What they're looking for
- PhD in Medicinal Chemistry, Chemical Biology, Pharmacology, or related field
- Industry experience is desirable, but the ability to work hard and learn fast is more important to us
- Deep understanding of small-molecule drug discovery and its relationship to human disease
- Able to work fluently at the interface of chemistry and biology
- Top-notch written and oral communication skills
- Strong experience in:
More about this role
General Proximity is a seed-stage startup developing the next generation of induced proximity medicines (IPMs). Our OmniTAC drug discovery engine furnishes molecules that co-opt existing cellular machinery to overcome therapeutic challenges, which have remained unapproachable to other modalities for decades.
We are seeking a first-rate medicinal chemist to help us pioneer this uncharted frontier of drug discovery.
A long-standing challenge in drug discovery is the development of molecules capable of modulating difficult or "undruggable" targets. Disease-causing proteins can be dysfunctional in many different ways, but our armamentarium for fixing them is quite limited. The most common mechanism of action for FDA-approved drugs is inhibition [1] , but there are many other possible perturbation types whose potential remains unrealized.
General Proximity is a seed-stage drug discovery company developing a novel platform technology to solve this problem. We make bifunctional drugs that induce the modification of drug targets by existing cellular machinery (rather than through direct modulation by the drug, the classical approach).
Historically, the development of technologies that...
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