Are you ready to lead the in vivo function at the center of Gordian’s target-discovery engine — from the screens that generate novel targets, through the studies that decide which ones advance, to the pharmacology that turns them into drugs? Gordian is the... Backed by Stanford.
About the role
You have a track record of success in high-agency work, consistently creating momentum rather than waiting for direction. You want to do your best work alongside exceptional teammates and are energized by environments where people push each other to think more clearly, work at a higher standard, and grow into better versions of themselves.
What they're looking for
- In vivo experience with oligonucleotides (ASO or siRNA), or with AAV and gene therapy
- Direct experience with HFpEF, CKD, or atherosclerosis models
- Advanced phenotyping: echocardiography, invasive hemodynamics, indirect calorimetry, EchoMRI or DEXA, or glucose clamps
- Experience building or scaling a vivarium or an in vivo group from small scale
- Partner- or BD-facing experience presenting preclinical data
- A peer-reviewed publication record in metabolic or cardiovascular physiology
More about this role
- Screens . Ensure the in vivo experiments that generate novel target hits are executed cleanly and on schedule.
- Target validation. Own the validation of screen hits with indication and ex vivo experts, define defensible evidence standards, and recommend which targets are strong enough to enter drug discovery.
- Drug discovery. Design pharmacodynamic and efficacy studies for targets in discovery, including small-molecule programs, and establish the evidence needed for program decisions.
Across all three you are Gordian’s design authority: model, modality, dose, route, controls, timepoints, group size, and statistical power. You will use pilots to retire risk, establish exposure and pharmacodynamics before efficacy, and — when a proposed experiment cannot answer its question — explain why and help the team build a better plan.
You will choose among oligonucleotides, AAV, and small molecules according to what each question requires, and you will bring in or build new disease models, delivery routes, and readouts when existing capabilities are insufficient. You do not need deep hands-on experience with every modality, but you must understand their in vivo strengths and limitations...
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