At insitro, we are building a different kind of drug company to bring better drugs faster to the patients who can benefit most. Through the power of machine learning (ML) and data at scale, we decode the complexities of biology to unlock transformative new... Backed by SoftBank VF, a16z and GV.
About the role
insitro is a physical AI company dedicated to unlocking causal human biology and accelerating the delivery of better medicines to patients. Our unique Virtual Human™ platform identifies novel, high-impact genetic intervention points, which our TherML™ platform translates into therapeutics—whether small molecules, biologics, or oligos.
What they're looking for
- Advanced Degree: Ph.D. in cell biology, biomedical engineering, cardiac physiology, or a related field, with at least 3 years of industry experience
- iPSC-CM Expertise: Deep hands-on experience in iPSC culture, cardiac directed differentiation, and iPSC-CM characterization across both 2D and 3D/EHT platforms
- Genetic Disease Modeling: Track record building and applying genetic iPSC-CM disease models — patient-derived lines, CRISPR-edited isogenic pairs — to study cardiovascular mechanisms
- Cardiovascular Biology: Strong foundational knowledge of cardiomyocyte biology and cardiovascular disease
- High-Content Imaging: Experience with high-content imaging and/or automated microscopy platforms, including image analysis pipelines
- Human Genetics: Familiarity with GWAS and human genetic evidence, and experience using these data to prioritize disease mechanisms or therapeutic targets
More about this role
insitro is a physical AI company dedicated to unlocking causal human biology and accelerating the delivery of better medicines to patients. Our unique Virtual Human™ platform identifies novel, high-impact genetic intervention points, which our TherML™ platform translates into therapeutics—whether small molecules, biologics, or oligos. With multiple programs in metabolic disease and neuroscience advancing toward the clinic, and our first IND submission slated for the second half of this year, we are at a pivotal inflection point.
We are seeking a Senior Scientist to join our cardiac disease biology team. In this role, you will own the development and application of iPSC-derived cardiomyocyte (iPSC-CM) models to study the genetic and molecular underpinnings of cardiovascular disease — working at the intersection of human stem cell biology, cardiac physiology, and scalable experimental platforms to generate the datasets that fuel our ML-driven drug discovery efforts. You will design and execute experiments, optimize differentiation and assay workflows, and partner closely with ML scientists, computational biologists, and chemists to connect cellular phenotypes to disease mechanisms...
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