Backed by a16z and GV.
About the role
At Maze Therapeutics, we believe precision medicine has the power to transform the lives of patients with both common and rare diseases. As Director of Clinical Operations, you will serve as Study Lead for a complex, global pivotal Phase 3 program within our chronic kidney disease (CKD) clinical development portfolio.
What they're looking for
- A Bachelor’s degree in a scientific or health-related field with 10–12+ years of clinical operations experience, including study leadership of Phase I–III trials
- Demonstrated success as the end-to-end operational lead for a complex large global Phase 3 study, including feasibility, startup, enrollment, study conduct, close-out, and inspection readiness
- Experience leading clinical trials in renal, or cardiometabolic diseases is strongly preferred
- Proven experience managing and developing teams, including coaching, mentoring, delegation, and supporting the growth of both managers and early-career professionals
- Expertise in global regulatory requirements (e.g., FDA, EMA, ANVISA, AMA, ICH-GCP), including direct experience supporting audits, inspections, and inspection-readiness activities
- Exceptional critical thinking and strategic judgment, with the ability to synthesize incomplete or evolving information, recommend a clear path forward, and influence decisions at study-team and executive levels
More about this role
At Maze Therapeutics, we believe precision medicine has the power to transform the lives of patients with both common and rare diseases. As Director of Clinical Operations, you will serve as Study Lead for a complex, global pivotal Phase 3 program within our chronic kidney disease (CKD) clinical development portfolio. You will be responsible for end-to-end study execution, working closely with cross-functional colleagues and external partners to translate development strategy into a practical study plan and deliver the study with quality, efficiency, and operational excellence.
Working closely with the study team, you will guide the Study Execution Team (SET), combining strategic oversight with hands-on execution to support successful trial delivery. This role requires someone who can synthesize complex information, anticipate challenges, facilitate cross-functional problem-solving, support timely decisions, and help teams identify the most effective path forward.
In partnership with the Oversight Director, you will support and develop a high-performing study team, oversee CRO and vendor activities, manage a substantial global study budget, and maintain continuous inspection...
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