Backed by a16z and GV.
About the role
At Maze Therapeutics, we believe that precision medicine has the power to transform the lives of patients with both common and rare diseases . As a Senior Clinical Trial Manager (Sr. CTM) at Maze Therapeutics, you’ll play a hands-on role in driving the execution of our clinical trials. You’ll have the opportunity to lead Early Development studies, work cross-functionally with internal teams and external partners, and ensure studies run efficiently and with the highest quality standards.
What they're looking for
- Demonstrated experience managing Phase I and early development trials across healthy volunteer and patient populations, including first-in-human and bridging studies
- Strong understanding of Clinical Pharmacology principles, including pharmacokinetics, pharmacodynamics, bioanalytical sampling, and PK data workflows
- Familiarity with regulatory guidelines (FDA, EMA, ICH-GCP)
- Strong executional leadership, problem-solving skills, and ability to manage cross-functional teams at the study level
- A startup mindset, willingness to roll up sleeves, and ability to work in a fast-paced, evolving, and collaborative team environment
- Excellent communication skills and the ability to manage cross-functional relationships effectively
More about this role
At Maze Therapeutics, we believe that precision medicine has the power to transform the lives of patients with both common and rare diseases . As a Senior Clinical Trial Manager (Sr. CTM) at Maze Therapeutics, you’ll play a hands-on role in driving the execution of our clinical trials. You’ll have the opportunity to lead Early Development studies, work cross-functionally with internal teams and external partners, and ensure studies run efficiently and with the highest quality standards. If you enjoy rolling up your sleeves, collaborating across teams, and bringing innovative medicines to patients, this role could be the perfect fit for you.
- Clinical Trial Execution & Leadership
Lead the planning, execution, and delivery of Clinical Pharmacology and early-phase trials (e.g., FIH, SAD/MAD, DDI, b ioavailability/bioequivalence and renal/hepatic impairment studies) from study design through CSR completion.
- Serve as the operational lead for assigned studies, managing cross-functional meetings and driving achievement of key milestones (FPI, enrollment completion, interim analyses, database lock, and CSR).
- Collaborate closely with Clinical Pharmacology, Clinical Science, and...
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