Dedicated to oncology, women’s health, and organ health. Natera’s cell-free DNA tests help protect health and inform more personalized decisions about care. Backed by Lightspeed and Sequoia.
About the role
About the Role: The Senior Product Manager, Oncology leads product development and commercial scale for Signatera, Natera's market-leading tumor-informed minimal residual disease (MRD) assay. This role owns laboratory turnaround time, throughput, and process stability across core lab sites. You will drive the change control review (CCR) pipeline end-to-end from root-cause investigation through requirements authorship, core team leadership, and post-launch hypercare monitoring.
What they're looking for
- Bachelor’s degree in life sciences, physical sciences, statistics, or engineering. Master’s or PhD preferred
- Minimum 5 years of professional experience, including 2-3 years in product management, commercialization, or strategic consulting within diagnostics, medical devices, or oncology
- Experience with products delivered as laboratory services strongly preferred
- Demonstrated experience driving data-driven process improvements using operational data and VOC to eliminate failure modes across the sample lifecycle
- Hands-on experience with quality systems (CAPA, nonconformance, change control) in a CLIA/CAP lab environment preferred
- Experience with SQL, Snowflake, Statistical Process Control (SPC), or continuous improvement frameworks (Lean, Six Sigma) preferred
More about this role
Remote | Bay Area, CA or Austin, TX - Must be located near a Natera laboratory with the ability to commute onsite a few times per month.
About the Role: The Senior Product Manager, Oncology leads product development and commercial scale for Signatera, Natera's market-leading tumor-informed minimal residual disease (MRD) assay. This role owns laboratory turnaround time, throughput, and process stability across core lab sites. You will drive the change control review (CCR) pipeline end-to-end from root-cause investigation through requirements authorship, core team leadership, and post-launch hypercare monitoring.
As the product lead for lab process performance, you will leverage operational and sequencing data, build capacity and financial models for equipment and automation investments, and serve as the subject matter expert to Software Engineering and Digital Product Management on instrument integration and LIMS requirements. This is an analytical, data-first, execution-heavy role for someone who bridges technical change control, product requirements, SQL queries, and lab floor operations.
- Own and execute the product roadmap for future Signatera features and service...
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