NewLimit is extending human healthspan by unlocking regenerative potential. Backed by Kleiner Perkins.
About the role
NewLimit is seeking a Principal/Senior Scientist to drive our mRNA process development and engineering efforts. As our mRNA Drug Substance Lead, you'll own mRNA process development from research-scale production through external GMP manufacturing. This is a hands-on, partially lab-based role requiring deep expertise in optimizing IVT and purification workflows. You'll be reporting directly to our Sr Director of Tech Ops and building out the mRNA Process Sciences team as our pipeline grows.
What they're looking for
- PhD in molecular biology, biochemistry, cell biology, or a related field, or equivalent industry experience (5+ years)
- Hands-on experience optimizing IVT reactions and familiarity with the specific challenges of scaling mRNA production (>10 mL scale)
- Hands-on experience optimizing column chromatography purification steps (i.e., oligo-dT) on AKTA systems
- Proficient in designing and executing UFDF/TFF steps
- Experience managing external CDMOs, through process development and GMP manufacturing
- Ability to perform and interpret basic mRNA analytical assays (Fragment Analyzer/TapeStation, restriction-digest + AGE, IP-RP-HPLC)
More about this role
NewLimit is a biotechnology company working to radically extend human healthspan. We’re developing medicines to treat age-related diseases by reprogramming the epigenome, a new therapeutic mechanism to restore regenerative potential in aged and diseased cells. We leverage functional genomics, pooled perturbation screening, and machine learning models to unravel the biology of epigenetic aging and disease using experiments of unprecedented scale.
NewLimit is seeking a Principal/Senior Scientist to drive our mRNA process development and engineering efforts. As our mRNA Drug Substance Lead, you'll own mRNA process development from research-scale production through external GMP manufacturing. This is a hands-on, partially lab-based role requiring deep expertise in optimizing IVT and purification workflows. You'll be reporting directly to our Sr Director of Tech Ops and building out the mRNA Process Sciences team as our pipeline grows.
- Establish and lead the mRNA process development capabilities at NewLimit, focused on optimizing IVT yield and downstream purification recovery for our preclinical programs.
- Manage the tech transfer and scale up activities at external CDMOs for GLP...
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