NewLimit is extending human healthspan by unlocking regenerative potential. Backed by Kleiner Perkins.
About the role
This is a hands-on bench role with real lipid design ownership. You will work closely with the Delivery Sciences and biology teams to design and build relevant Ionizable and targeting lipids portfolio for New Limit’s pipeline programs.
What they're looking for
- PhD in Chemistry, Pharmaceutical Chemistry, or a related discipline, plus 1–2 years of relevant work, or an MS with 5 years of focused lipid design experience for liposomal or lipid nanoparticle applications
- Strong skill set in the design and synthesis of new lipids or other delivery chemistries, performed personally rather than with a supervisor directing each step
- SAR-driven design, synthesis, purification, and characterization of ionizable lipids and PEG-lipid conjugates, using tools such as ChemDraw, Sci-Finder, Reaxsys, and AI-based SAR prediction tools for tLNP applications
- Practical purification skills spanning normal- and reverse-phase chromatography and preparative HPLC
- Analytical characterization across LC-CAD, LC-UV, LC-MS/MS, and NMR (¹H, ¹³C, and ³¹P as needed), with the ability to deconvolute the data to produce well-characterized lipids
More about this role
NewLimit is a biotechnology company working to radically extend human healthspan. We’re developing medicines to treat aging by reprogramming the epigenome, a new therapeutic mechanism to restore youthful function in aged cells. We’ve built the world’s leading experimental and artificial intelligence system to discover reprogramming medicines at massive scale. Our first products are focused on restoring youthful metabolic, endothelial, and immune function.
NewLimit is seeking a Lipid Chemist to design, synthesize, and characterize ionizable lipids, PEG-lipid Conjugates, peptide and antibody conjugates to build our targeting LNP platform with a particular focus on getting nucleic acid payloads into target cells and tissues beyond the liver.
This is a hands-on bench role with real lipid design ownership. You will work closely with the Delivery Sciences and biology teams to design and build relevant Ionizable and targeting lipids portfolio for New Limit’s pipeline programs.
- Design new ionizable lipids and lipid conjugates for antibodies, peptides, and other targeting moieties across multiple structural families, pushing the platform beyond current-generation materials.
- Devise and...
Browse similar: Startup jobs · San Francisco Bay Area