Backed by a16z and Lux.
About the role
We are seeking a scientist with cheminformatics expertise to join our dynamic and multidisciplinary research team. A core focus of your role will be to guide assay development and evaluate the resulting data using chemical reasoning, expanding the capabilities of the Octant Navigator platform.
What they're looking for
- A PhD in Chemistry, Cheminformatics, Chemical Biology, Computational Chemistry, or a related discipline
- 3-5 years of research experience. Industry preferred, but exceptional recent PhD graduates with strong relevant experience are encouraged to apply
- Expertise in organic and/or medicinal chemistry, ideally including DMPK, ability to reason about structure-property relationships
- Practical analytical chemistry knowledge, especially chromatography (HPLC, SFC, LC-MS): retention behavior, failure modes, and ability to differentiate signal from artifact
- Strong statistics and data science fundamentals, including experiment design, batch effects, and uncertainty, ability to develop quantitative assays and generate and analyze large datasets
- Solid software skills: fluency in Python and/or R and the standard cheminformatics stack (e.g., RDKit, pandas), writing reproducible analyses that other people can actually run and build on
More about this role
Octant is a clinical-stage drug discovery company developing correctors for protein misfolding diseases with active programs in rare diseases and oncology. Octant’s platform, The Navigator, combines high-throughput synthetic biology, generative chemistry, and AI/ML to discover and develop therapeutics against complex cellular mechanisms in human cells.
We are seeking a scientist with cheminformatics expertise to join our dynamic and multidisciplinary research team. A core focus of your role will be to guide assay development and evaluate the resulting data using chemical reasoning, expanding the capabilities of the Octant Navigator platform. You will begin with our OpenADMET effort, turning high-throughput ADMET datasets into chemical insight that serves both Octant's drug programs and the open science community, and broaden into internal platform work over your first year.
You will apply chemical intuition and statistical rigor to every stage of the work, from assay development to compound selection to analysis at scale. You are motivated by the mission of Octant and have a team-first mindset. You bring excellent communication skills and an ability to thrive in a dynamic and...
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