Drug development shouldn’t be guesswork, not when patients are waiting. Pathos is building a next-generation biotech with AI at the core. Not as a feature, but as the operating system for how medicines get developed. Backed by NEA.
About the role
The Director, Clinical Science is a hands-on member of the Clinical Development team, responsible for the day-to-day scientific execution of Pathos oncology programs across active Phase 1 and Phase 2 trials. You own protocol development, data review, clinical document authorship, and site-level scientific support from study startup through closeout.
What they're looking for
- Author and own study protocols from first draft through amendments, including study design, eligibility criteria, endpoint selection, and safety monitoring plans
- Write and maintain Investigator Brochures, informed consent forms, Clinical Study Reports, and briefing documents in partnership with Clinical Operations and Medical Writing
- Direct AI agents to compile source data, structure document drafts, and run quality checks, then apply your scientific judgment to finalize each deliverable
- Conduct ongoing review of safety and efficacy data across active studies, including eligibility confirmation, protocol deviation assessment, and adverse event review
- Prepare materials and lead deliverables for data monitoring committees and other clinical review bodies
- Collaborate with data management on eCRF development, edit check design, and database lock activities
More about this role
About the Role
The Director, Clinical Science is a hands-on member of the Clinical Development team, responsible for the day-to-day scientific execution of Pathos oncology programs across active Phase 1 and Phase 2 trials. You own protocol development, data review, clinical document authorship, and site-level scientific support from study startup through closeout.
You will work closely with Clinical Operations, Translational Medicine and Biomarker Science to keep studies running with scientific rigor at every step. You will report to the Chief Development Lead.
At Pathos, AI agents handle literature compilation, document formatting, data extraction, and status tracking. That means you spend your time on the science reviewing data, resolving eligibility questions, sharpening protocols, and making the calls that move programs forward, not on administrative overhead.
What You Will Do
Own protocol development and clinical documents
- Author and own study protocols from first draft through amendments, including study design, eligibility criteria, endpoint selection, and safety monitoring plans.
- Write and maintain Investigator Brochures, informed consent forms, Clinical Study Reports,...
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