Pivotal Life Sciences specializes in providing capital to innovative companies developing therapeutic products to address major unmet medical needs.
About the role
Job Summary: We are seeking a highly motivated and experienced scientific leader to join our team as a Senior Scientist or Principal Scientist, Bioprocess Sciences. This role will provide deep technical expertise in bacterial recombinant protein production programs that support research and development. The successful candidate will drive process development, scale-up strategy, and external manufacturing oversight in a fast-moving, collaborative environment.
What they're looking for
- D. or M.S. in Chemistry, Biology, Biochemistry, Biomedical Engineering, Chemical Engineering, or a related field
- 6-10+ years of progressive experience in bacterial recombinant protein expression, purification, and bioprocess development
- Demonstrated experience leading projects and mentoring or managing scientists
- Hands-on expertise with recombinant protein purification using FPLC and chromatography approaches such as affinity, ion exchange, hydrophobic interaction, size exclusion, or mixed-mode chromatography
- Experience developing and executing normal-flow filtration, tangential-flow filtration, and UF/DF processes
- Strong working knowledge of recombinant protein analytical characterization using techniques such as HPLC, SDS-PAGE, Western blotting, ELISA, and other biochemical or biophysical assays
More about this role
Title: Senior Scientist / Principal Scientist, Bioprocess Sciences
Job Type: Full-Time
About Us: We are an innovative, stealth-mode biotech focused on developing best-in-class delivery for in vivo gene editing.
Job Summary: We are seeking a highly motivated and experienced scientific leader to join our team as a Senior Scientist or Principal Scientist, Bioprocess Sciences. This role will provide deep technical expertise in bacterial recombinant protein production programs that support research and development. The successful candidate will drive process development, scale-up strategy, and external manufacturing oversight in a fast-moving, collaborative environment. Title and compensation will be commensurate with experience.
- Serve as a technical expert for recombinant protein expression, downstream purification, and analytical characterization.
- Design, develop, optimize, and scale bacterial culture, recombinant protein purification, and downstream processes for internal research programs and external manufacturing activities.
- Develop robust purification strategies using multiple chromatography modalities, including affinity, ion exchange, hydrophobic interaction, size...
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