The next frontier is authoring new biology, and with AI, we have the power to write the future—creating solutions that transform medicine, agriculture, and beyond. Backed by Insight and Air Street.
About the role
Profluent is seeking an exceptional Executive Director / Vice President, Biology & Translational Pharmacology to lead the scientific strategy and execution of our gene editing therapeutic portfolio. You will help realize the full potential of Profluent’s AI-designed, customized base editors by advancing a defined initial pipeline of genetic medicines for severe inborn metabolic diseases.
What they're looking for
- PhD, MD, DVM, PharmD, or equivalent advanced degree in pharmacology, molecular biology, genetics, physiology, hepatology, bioengineering, medicine, or a related discipline
- PhD in related discipline with significant (12+ years) biopharma R&D experience, with a strong track record in genetic medicines, liver biology, translational pharmacology, and preclinical development
- Deep experience with genetic medicines or advanced therapeutic modalities, such as RNAi, antisense oligonucleotides, mRNA/LNP therapeutics, gene therapy, genome editing, or related platforms
- Deep understanding of liver biology and metabolic disease, with the ability to connect human genetics, disease biology, pharmacology, biomarkers, translational models, and development strategy
- Extensive experience with rare liver diseases, lipid biology, hepatology, fibrosis biology, and / or metabolic liver disease
- Demonstrated ability to lead multidisciplinary scientific teams, including direct management of senior scientists or functional leaders and leadership of matrixed drug-discovery project teams
More about this role
Profluent is the frontier AI lab for biology. Profluent builds powerful foundation models for all of life's molecules, unlocking solutions that transform medicine, agriculture, and beyond. Founded in 2022 and headquartered in Emeryville, CA, Profluent is backed by leading investors including Altimeter Capital, Bezos Expeditions, Spark Capital, Insight Partners, Air Street Capital, AIX Ventures, and Convergent Ventures and has raised over $150M to date.
Profluent is seeking an exceptional Executive Director / Vice President, Biology & Translational Pharmacology to lead the scientific strategy and execution of our gene editing therapeutic portfolio. You will help realize the full potential of Profluent’s AI-designed, customized base editors by advancing a defined initial pipeline of genetic medicines for severe inborn metabolic diseases.
Our initial therapeutic focus for this role is liver-directed customized base editing, with future opportunities to expand into additional tissues and therapeutic areas as Profluent’s platform and portfolio grow. You will bring deep expertise in liver biology, metabolic disease, pharmacology, and in vivo disease models, along with the strategic...
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