The next frontier is authoring new biology, and with AI, we have the power to write the future—creating solutions that transform medicine, agriculture, and beyond. Backed by Insight and Air Street.
About the role
We are seeking a talented, self-motivated, and highly resourceful Scientist I / Scientist II to serve as a foundational scientist in establishing our next-generation Targeted Lipid Nanoparticle (tLNP) platform. This role is central to our strategy of achieving extrahepatic tissue tropism for next-generation genetic medicines.
What they're looking for
- Hands-on experience with LNP assembly platforms (microfluidic/NanoAssemblr, T-junction, or ethanol injection) and surface bioconjugation techniques to functionalize nanoparticles with targeting moieties
- Demonstrated understanding and experience in shifting nanoparticle biodistribution/tropism through lipid compositional tweaking, molar ratio modification, or structural lipid alteration
- Hands-on proficiency in mammalian cell culture and running quantitative cell-based assays (Flow Cytometry/FACS, reporter assays, ELISAs)
- Understanding of systemic nanoparticle distribution, protein corona formation, vascular barriers, and in vivo study design principles. (Hands-on animal dosing or ex vivo tissue processing experience is not required)
- Entrepreneurial drive and organizational skills suited for building assays, protocols, and workflows in an early-stage, growing R&D environment
More about this role
Profluent is the frontier AI lab for biology. Profluent builds powerful foundation models for all of life's molecules, unlocking solutions that transform medicine, agriculture, and beyond. Founded in 2022 and headquartered in Emeryville, CA, Profluent is backed by leading investors including Altimeter Capital, Bezos Expeditions, Spark Capital, Insight Partners, Air Street Capital, AIX Ventures, and Convergent Ventures and has raised over $150M to date.
We are seeking a talented, self-motivated, and highly resourceful Scientist I / Scientist II to serve as a foundational scientist in establishing our next-generation Targeted Lipid Nanoparticle (tLNP) platform. This role is central to our strategy of achieving extrahepatic tissue tropism for next-generation genetic medicines.
In this position, you will own the end-to-end design, formulation, bioconjugation, and physicochemical characterization of novel tLNPs. You will establish our internal in vitro cell culture and assay pipeline to validate targeting and cellular uptake, while serving as the primary technical interface for in vivo studies. This is a high-visibility, high-impact role ideal for an agile scientist with strong drug...
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