Backed by GV.
About the role
We are seeking a creative and experienced biophysicist to accelerate target validation, hit confirmation, and drug discovery across our oncology discovery portfolio. This role will leverage orthogonal biophysical approaches to characterize protein quality and molecular interactions enabling confident progression from screening hits to mechanistically validated leads.
What they're looking for
- Ph.D. in Biophysics, Biochemistry, Structural Biology, or related discipline with 8+ years of industry experience in drug discovery
- Demonstrated scientific judgment in experimental design and execution, data interpretation, and selecting appropriate orthogonal approaches to address challenging discovery questions
- Extensive hands-on experience in protein biochemistry and biophysics, including recombinant protein characterization and work with challenging proteins and multi-protein complexes
- Demonstrated ability to integrate biophysical data with medicinal chemistry, structural biology, and functional biology to guide project decisions
- Proven ability to work independently in a fast-paced discovery environment while contributing effectively as a collaborative team member with willingness to learn and improve
- Experience with molecular glues, induced proximity, or complex protein–protein interaction systems, including analysis of ternary or higher-order complex formation and stability
More about this role
Revolution Medicines is a global, commercial-state oncology company dedicated to discovering, developing and delivering innovative medicines for patients with RAS-addicted cancers. Leveraging its differentiated RAS(ON) tri-complex inhibitor platform, the company is advancing a broad, integrated portfolio of oral RAS(ON) inhibitors designed to directly target the active, cancer-driving state of RAS. Founded on rigorous scientific inquiry and a willingness to challenge long-held assumptions, Revolution Medicines is committed to changing the trajectory of disease for patients with RAS-addicted cancers worldwide.
Our people are united by a shared way of working: follow the science, challenge assumptions, act with urgency and hold ourselves to a high standard of rigor—all in service of patients.
We are seeking a creative and experienced biophysicist to accelerate target validation, hit confirmation, and drug discovery across our oncology discovery portfolio. This role will leverage orthogonal biophysical approaches to characterize protein quality and molecular interactions enabling confident progression from screening hits to mechanistically validated leads. The successful candidate...
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