Shasqi uses click chemistry to target cancer drugs directly to the tumor, minimizing side effects and potentially improving the therapeutic index. Backed by Y Combinator.
About the role
We are seeking an experienced and hands-on Principal Scientist, ADME/PK to lead and contribute to pharmacokinetics, biodistribution, and translational modeling efforts for a next-generation tumor targeting technology based on a click chemistry enabled pre-targeting. You will work at the interface of chemistry, biology, and translational sciences to design and interpret studies that contribute to therapeutic design, candidate selection, IND-enablement, and clinical strategy in a fast-paced startup environment.
What they're looking for
- PhD in Pharmacokinetics, Pharmaceutical Sciences, Bioengineering, or related field
- 4+ years of industry experience in ADME/PK (biotech/pharma), including ADME/PK leadership on therapeutic programs
- Deep expertise in PK of biologics and/or targeted delivery systems (e.g., ADCs, radioconjugates, bispecifics)
- Strong experience designing and interpreting in vivo PK and biodistribution studies
- Demonstrated experience with QSP and PK/PD modeling
- Experience with modeling tools (e.g., Phoenix WinNonlin, NONMEM, Monolix, MATLAB, or similar)
More about this role
What if this meant you could get potent therapy directly to the tumor, sparing healthy cells?
That’s the future we’re building at Shasqi, using Nobel Prize-winning science to unleash powerful therapies only where they’re needed.
We’re a small, driven team encompassing broad backgrounds and experiences, united by a single mission: make cancer treatments more effective with minimal side effects.
We move fast because speed matters to cancer patients.
We aim to communicate openly and challenge ideas regardless of job title.
We are bold, take risks, and push boundaries being led by science.
We operate with humble confidence: meaning we can balance our sense of capability and conviction without ego, while being humble to seek advice and learn from our mistakes.
If that fires you up, come build the future of cancer therapy with us!
Are mission driven and eager to do the best work of your career, developing novel therapies that will transform cancer treatment.
Can balance scientific rigor with a fast-paced environment.
Are comfortable with ambiguity and making decisions in the face of uncertainty.
Operate with a strong sense of agency and invite feedback and advice.
Can challenge...
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