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Principal Scientist, Protein Engineering

Xaira · South San Francisco, California, United States · On-site

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About Xaira

We’re pioneering the discovery and development of life-changing medicines through the transformative power of artificial intelligence. Backed by Lightspeed, NEA and Sequoia.

About the role

As a member of the Protein Engineering team at Xaira, you will play a critical role in the AI-driven discovery and development of protein therapeutics, integrating experimental protein engineering with computational design.

What they're looking for

  • Ph.D. in a relevant scientific discipline, with a strong foundation in molecular biology, biochemistry, structural biology, or a related field
  • At least 6 years of industry experience in biotech or biopharma R&D supporting large-molecule therapeutic programs
  • Extensive hands-on experience in protein engineering, including structural and functional characterization of antibodies and other proteins using advanced analytical methods
  • Deep expertise in antibody formats, production, purification, and characterization
  • Proficiency in developability assessments and stability studies
  • Proficiency with protein visualization and structure prediction tools, such as PyMOL and AlphaFold
More about this role

Xaira is an innovative biotech startup focused on leveraging AI to transform drug discovery and development. The company is leading the development of generative AI models to design protein and antibody therapeutics, enabling the creation of medicines against historically hard-to-drug molecular targets. It is also developing foundation models for biology and disease to enable better target elucidation and patient stratification. Collectively, these technologies aim to continually enable the identification of novel therapies and to improve success in drug development. Xaira is headquartered in the San Francisco Bay Area, Seattle, and London.

As a member of the Protein Engineering team at Xaira, you will play a critical role in the AI-driven discovery and development of protein therapeutics, integrating experimental protein engineering with computational design.

As a Principal Scientist, you will provide scientific and technical leadership from program conception through early discovery and lead optimization. You will partner closely with computational protein designers to guide AI-driven design campaigns and develop experimental strategies to evaluate designed molecules. You will...

Read the full posting on Xaira's site ↗

Drug Discovery & Development

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