Who we are. Arbor Biotechnologies, a clinical stage, next-generation gene editing company based in Cambridge, MA, is advancing a portfolio of first-in-class genomic medicines addressing serious diseases for which there are no existing functional cures, with a... Backed by Accel.
About the role
We are seeking an Associate Scientist to participate in protein engineering campaigns for our cutting-edge genome editing tools towards generating best-in-class molecules. You will play a key role in supporting selection and generation of protein mutants/variants, for testing in cellular screens, downstream analytics, and communicating results within the team. You will also work cross-functionally with other teams to support upstream design and downstream hand-off and testing.
What they're looking for
- Independently plan, execute, optimize, and troubleshoot experiments supporting protein engineering campaigns for genome editing tools
- Contribute to the design, generation, and evaluation of protein mutants/variants, including recommending experimental approaches, controls, and follow-up studies
- Design and execute cell-based screening workflows using transient transfection, nucleofection, and transduction in dividing and non-dividing cell models
- Design, package, and evaluate AAVs for protein variant testing, including troubleshooting production, delivery, and performance issues
- Synthesize, purify, characterize, and test IVT-generated mRNA, including troubleshooting quality, yield, and cellular delivery
- Prepare sequencing libraries and analyze experimental outputs to assess editing outcomes, variant performance, and experimental quality
More about this role
About the Role.
We are seeking an Associate Scientist to participate in protein engineering campaigns for our cutting-edge genome editing tools towards generating best-in-class molecules. You will play a key role in supporting selection and generation of protein mutants/variants, for testing in cellular screens, downstream analytics, and communicating results within the team. You will also work cross-functionally with other teams to support upstream design and downstream hand-off and testing. This role is ideal for a detail-oriented and motivated molecular biologist with a willingness to learn and a team-first mentality.
What you'll do.
- Independently plan, execute, optimize, and troubleshoot experiments supporting protein engineering campaigns for genome editing tools.
- Contribute to the design, generation, and evaluation of protein mutants/variants, including recommending experimental approaches, controls, and follow-up studies.
- Design and execute cell-based screening workflows using transient transfection, nucleofection, and transduction in dividing and non-dividing cell models.
- Design, package, and evaluate AAVs for protein variant testing, including troubleshooting...
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