Who we are. Arbor Biotechnologies, a clinical stage, next-generation gene editing company based in Cambridge, MA, is advancing a portfolio of first-in-class genomic medicines addressing serious diseases for which there are no existing functional cures, with a... Backed by Accel.
About the role
Before any of our CNS gene editing programs can move toward the clinic, we need to see in tissue where an editor went, whether it reached its target, and what it did there. This role produces that evidence. You’ll run and quantify the histology assays on rodent and non-human primate tissue that our program teams use to decide what moves forward. This role reports to the Senior Scientist, In Vivo Pharmacology. It is on-site in Cambridge, typically 4-5 days per week. Found on 1752vc Careers, the job board for startup and VC roles.
What they're looking for
- Develop, optimize, and run IHC, IF, and ISH/RNAscope assays on preclinical CNS tissue
- Process, stain, and image CNS tissue from rodent and non-human primate studies
- Quantify assay readouts in image analysis software such as HALO, QuPath, or ImageJ/Fiji
- Generate the histology data used to assess biodistribution, target engagement, pharmacodynamic activity, editing outcomes, and safety
- Analyze and graph results in GraphPad Prism and summarize them clearly for project scientists
- Plan histology endpoints and tissue readouts for in vivo studies with the study lead
More about this role
Why this role matters.
Before any of our CNS gene editing programs can move toward the clinic, we need to see in tissue where an editor went, whether it reached its target, and what it did there. This role produces that evidence. You’ll run and quantify the histology assays on rodent and non-human primate tissue that our program teams use to decide what moves forward.
This role reports to the Senior Scientist, In Vivo Pharmacology. It is on-site in Cambridge, typically 4-5 days per week.
What you'll own.
- Develop, optimize, and run IHC, IF, and ISH/RNAscope assays on preclinical CNS tissue.
- Process, stain, and image CNS tissue from rodent and non-human primate studies.
- Quantify assay readouts in image analysis software such as HALO, QuPath, or ImageJ/Fiji.
- Generate the histology data used to assess biodistribution, target engagement, pharmacodynamic activity, editing outcomes, and safety.
- Analyze and graph results in GraphPad Prism and summarize them clearly for project scientists.
- Plan histology endpoints and tissue readouts for in vivo studies with the study lead.
- Present results in group meetings and cross-functional study discussions.
- Troubleshoot assays,...
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