Who we are. Arbor Biotechnologies, a clinical stage, next-generation gene editing company based in Cambridge, MA, is advancing a portfolio of first-in-class genomic medicines addressing serious diseases for which there are no existing functional cures, with a... Backed by Accel.
About the role
Our gene editing programs for neurodegenerative diseases can only advance if in vivo studies show that an editor works in a living animal. This role carries those studies from dosing through tissue collection to the molecular readout. The data you generate feeds the preclinical and IND-enabling work that decides whether a program moves forward. This role reports to the Senior Scientist, In Vivo Pharmacology. It is on-site in Cambridge, typically 4–5 days per week. Found on 1752vc Careers, the job board for startup and VC roles.
What they're looking for
- Run in vivo pharmacology studies in rodents, including dosing, monitoring, clinical observations, blood collection, tissue harvest, and necropsy
- Set up and schedule studies, and coordinate between the laboratory and the animal facility
- Process tissues and biological samples, and isolate DNA, RNA, and protein for molecular, biochemical, and pharmacodynamic analysis
- Run assays such as qPCR/ddPCR, RT-qPCR, Western blot, Simple Western/Jess, ELISA, or RNAscope
- Analyze, interpret, and graph study and assay data in GraphPad Prism and other analysis tools
- Present findings, study progress, and data summaries to project teams and cross-functional collaborators
More about this role
Why this role matters.
Our gene editing programs for neurodegenerative diseases can only advance if in vivo studies show that an editor works in a living animal. This role carries those studies from dosing through tissue collection to the molecular readout. The data you generate feeds the preclinical and IND-enabling work that decides whether a program moves forward.
This role reports to the Senior Scientist, In Vivo Pharmacology. It is on-site in Cambridge, typically 4–5 days per week.
What you'll own.
- Run in vivo pharmacology studies in rodents, including dosing, monitoring, clinical observations, blood collection, tissue harvest, and necropsy.
- Set up and schedule studies, and coordinate between the laboratory and the animal facility.
- Process tissues and biological samples, and isolate DNA, RNA, and protein for molecular, biochemical, and pharmacodynamic analysis.
- Run assays such as qPCR/ddPCR, RT-qPCR, Western blot, Simple Western/Jess, ELISA, or RNAscope.
- Analyze, interpret, and graph study and assay data in GraphPad Prism and other analysis tools.
- Present findings, study progress, and data summaries to project teams and cross-functional collaborators.
- Keep study...
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