Backed by Norwest.
About the role
The Senior Scientist, Formulation Development will play a key role in advancing Avalyn's pipeline of inhaled therapies for pulmonary fibrosis. This position will focus on the development and optimization of solution and dry powder formulations, aerosol performance, and drug-device compatibility to support clinical development, process scale-up, and future commercial manufacturing.
What they're looking for
- Ph.D. in Pharmaceutical Sciences, Chemical Engineering, Chemistry, Materials Science, or a related scientific discipline is required
- A minimum of 8 plus years of industry experience in pharmaceutical formulation development following completion of a Ph.D. is required
- Experience developing inhaled pharmaceutical products is highly preferred
- Deep understanding of aerosol science and pulmonary drug delivery is preferred
- Hands-on experience with solution and dry powder inhalation formulations is desirable
- Experience working with inhalation devices and drug-device combination products is preferred
More about this role
Avalyn aims to transform the treatment paradigm for pulmonary fibrosis and other serious, rare respiratory diseases. The company is advancing optimized inhaled formulations of established antifibrotic medicines designed to deliver drug directly to the lungs, enhance local efficacy, and reduce systemic side effects. Avalyn’s AP01 program is an optimized inhaled formulation of pirfenidone currently being evaluated in MIST, a global Phase 2b clinical trial in patients with progressive pulmonary fibrosis (PPF). AP01 has demonstrated encouraging safety and clinical activity across Phase 1b and an ongoing, multi-year open-label extension trial, with long-term data supporting the potential to preserve lung function while improving tolerability relative to historical oral pirfenidone. Avalyn’s AP02 program is an optimized inhaled formulation of nintedanib currently being evaluated in AURA, a global Phase 2 clinical trial in patients with idiopathic pulmonary fibrosis (IPF). Avalyn is also advancing AP03, an inhaled fixed-dose combination of pirfenidone and nintedanib, designed to deliver multiple antifibrotic mechanisms through a single lung-targeted platform. By leveraging its...
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