About Cartography Biosciences Cartography Biosciences is advancing a differentiated oncology pipeline of antibody-based therapies designed to target tumors with unprecedented precision. Backed by a16z.
About the role
We are looking for a Principal Scientist or Associate Director to lead developability and protein sciences for our bispecific and multispecific antibody programs, including T-cell engagers. You will own the biophysical and developability screening that informs lead selection, along with the expression and purification that supplies it, working in house and with external partners. You will manage and grow a small team of scientists and play a leading role on cross-functional therapeutic program teams. Found on 1752vc Careers, the job board for startup and VC roles.
What they're looking for
- Deliver developability and biophysical data for therapeutic programs as candidates advance from hit screening through lead optimization to development candidate nomination
- Integrate in silico biophysical property assessment (e.g. sequence liabilities, surface patch analysis, aggregation propensity) with experimental data to prioritize and engineer candidates
- Characterize advanced leads and development candidates in depth through stress and forced degradation studies, PTM mapping (e.g. peptide mapping LC-MS), and early formulation development
- Help define and own the developability criteria at each program decision gate, and apply them consistently across programs
- Expand the throughput, robustness, and technical scope of our protein analytics capabilities to support AI/ML-driven antibody engineering
- Oversee research-stage protein production from 1 mL to 10 L scale, in house and through external partners, run as a service with clear intake, prioritization, turnaround, and quality acceptance of incoming material
More about this role
About the Role
We are looking for a Principal Scientist or Associate Director to lead developability and protein sciences for our bispecific and multispecific antibody programs, including T-cell engagers. You will own the biophysical and developability screening that informs lead selection, along with the expression and purification that supplies it, working in house and with external partners. You will manage and grow a small team of scientists and play a leading role on cross-functional therapeutic program teams.
This is a hands-on, hybrid role based onsite in South San Francisco, with roughly half of your time at the bench alongside the team. You will turn developability data into program decisions and work with Antibody Engineering, Pharmacology, and program leadership to act on them. We expect the scope of the role to grow with the team and the pipeline.
Key Responsibilities
Developability & Biophysical Characterization
- Deliver developability and biophysical data for therapeutic programs as candidates advance from hit screening through lead optimization to development candidate nomination.
- Own the developability screening cascade, including thermal stability (e.g. DSF,...
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