Patient-Centric Mission. Asset-Centric Approach. We’re pursuing our Orexin Receptor 2 Agonist Program to bring potentially transformative treatment options to patients with sleep-wake, neurological, neurodegenerative and neuropsychiatric disorders.... Backed by Foresite Capital.
About the role
Centessa Pharmaceuticals, a wholly owned subsidiary of Eli Lilly and Company, is a clinical-stage company developing orexin receptor 2 (OX2R) agonists as a new class of medicines for the treatment of narcolepsy and potentially other sleep-wake disorders. Centessa’s lead investigational candidate – cleminorexton (formerly ORX750) – is being developed for narcolepsy type 1, narcolepsy type 2, and idiopathic hypersomnia. Found on 1752vc Careers, the job board for startup and VC roles.
What they're looking for
- Bachelor’s degree in a scientific or health ‑ related discipline
- 5+ years clinical trial management experience within an industry sponsor environment, supporting drug development programs
- Experience managing clinical trials in CNS therapeutic development strongly preferred
- Proven ability to manage global clinical studies, including coordination with investigators, CROs, and functional vendors
- Strong working knowledge of ICH guidelines, GCP, and global regulatory requirements applicable to clinical trials
- Solid understanding of project management principles, including planning and managing timelines, resources, budgets, and risk–benefit trade‑ offs, PMP or similar training is a plus
More about this role
Centessa Pharmaceuticals, a wholly owned subsidiary of Eli Lilly and Company, is a clinical-stage company developing orexin receptor 2 (OX2R) agonists as a new class of medicines for the treatment of narcolepsy and potentially other sleep-wake disorders. Centessa’s lead investigational candidate – cleminorexton (formerly ORX750) – is being developed for narcolepsy type 1, narcolepsy type 2, and idiopathic hypersomnia. Centessa's OX2R agonist portfolio includes additional clinical and preclinical-stage assets with potential utility across a broader range of neurological, neurodegenerative, and neuropsychiatric conditions.
Headquartered in Boston, Massachusetts, Centessa was recognized as a Great Place to Work ® in 2026.
Centessa is seeking a (contract to hire) Clinical Trial Manager to lead the execution of mid ‑ to late ‑ stage global clinical studies from study start ‑ up through close ‑ out and clinical study report. This role is a temporary position with the potential to convert to a permanent role, responsible for day ‑ to ‑ day trial management, coordinating internal cross ‑ functional teams and overseeing CROs and external vendors to ensure studies are delivered on time,...
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