Genentech discovers, develops, manufactures and commercializes treatments for patients with serious and life-threatening medical conditions. Backed by North Carolina Biotechnology Center.
About the role
This role also includes developing and leading hypothesis-driven translational research focused on identifying and developing novel biomarkers of therapeutic response and resistance, as well as uncovering disease-specific mechanistic insights. The candidate will collaborate closely on cross-functional biomarker efforts, working with colleagues across Research, Clinical Development, Diagnostics, Computational Science, Clinical Pharmacology, Regulatory, and Biostatistics. Found on 1752vc Careers, the job board for startup and VC roles.
What they're looking for
- PhD, MD, or MD/PhD in molecular biology, cancer biology, immunology, computational biology, bioinformatics, or a related field
- Demonstrated scientific excellence through impactful graduate or postdoctoral research, including first-author publications in high-quality peer-reviewed journals
- 3-5 years of experience with translational research approaches including molecular profiling, multi-omic analyses, spatial biology, single-cell technologies, and/or functional immune assays is preferred
- Interest in leveraging innovative computational approaches, including emerging AI-enabled and agentic AI tools, to support biomarker discovery, translational insight generation, and data interpretation is a plus
- Strong scientific curiosity with the ability to independently develop hypotheses and translate complex biological observations into mechanistic insight
- Excellent written and verbal communication skills, with the ability to communicate complex scientific concepts to multidisciplinary audiences
More about this role
We advance science so that we all have more time with the people we love. The Principal Scientist in Translational Medicine Oncology will support one or more translational programs contributing to the clinical development of oncology therapeutics. The successful candidate will be a key member of the Translational Medicine subteam, designing, developing, and implementing pharmacodynamic and predictive biomarker strategies across early- and late-stage clinical trials.
This role also includes developing and leading hypothesis-driven translational research focused on identifying and developing novel biomarkers of therapeutic response and resistance, as well as uncovering disease-specific mechanistic insights. The candidate will collaborate closely on cross-functional biomarker efforts, working with colleagues across Research, Clinical Development, Diagnostics, Computational Science, Clinical Pharmacology, Regulatory, and Biostatistics.
Strong scientific communication and collaboration with both internal and external stakeholders—including key opinion leaders (KOLs) and academic partners—will be critical to advancing translational objectives and disease area strategies in oncology. The...
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