Genentech discovers, develops, manufactures and commercializes treatments for patients with serious and life-threatening medical conditions. Backed by North Carolina Biotechnology Center.
About the role
The Cardiovascular, Renal and Metabolism (CVRM) Research Biology group within Genentech Research and Early Development (gRED) is seeking an innovative and highly motivated Scientist 3 to advance our extra-hepatic, cell- and tissue-selective drug delivery platforms. In this laboratory-based role, you will lead the biological discovery and validation of novel cell-surface receptors to enable targeted delivery of nucleic acid therapeutics (such as siRNAs and ASOs). Found on 1752vc Careers, the job board for startup and VC roles.
What they're looking for
- Develop and execute an overarching biological strategy to identify, prioritize, and validate cell-surface receptors capable of mediating selective nucleic acid delivery to CVRM-relevant tissues
- Establish, culture, and characterize physiologically relevant in vitro and ex vivo cellular systems (including striated muscle) for targeted-delivery evaluation
- Design and implement quantitative mechanistic assays to assess ligand-receptor binding, occupancy, internalization kinetics, intracellular trafficking, and endosomal escape
- Evaluate novel targeting ligands and bioconjugates (such as antibody- or peptide-oligonucleotide conjugates) for functional cargo delivery, downstream pharmacodynamics, and target gene modulation
- Apply genetic and molecular perturbation tools, including CRISPR and RNAi, alongside biochemical methods to establish definitive receptor dependency and mechanism of action
- Design and execute preclinical in vivo biodistribution and proof-of-concept pharmacology studies to demonstrate disease-modifying therapeutic potential
More about this role
The Opportunity
A healthier future. It’s what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love. That’s what makes us Genentech.
The Cardiovascular, Renal and Metabolism (CVRM) Research Biology group within Genentech Research and Early Development (gRED) is seeking an innovative and highly motivated Scientist 3 to advance our extra-hepatic, cell- and tissue-selective drug delivery platforms. In this laboratory-based role, you will lead the biological discovery and validation of novel cell-surface receptors to enable targeted delivery of nucleic acid therapeutics (such as siRNAs and ASOs). Working in close cross-functional partnership with therapeutic discovery, vector design, proteomics, and disease biology teams, you will directly shape next-generation delivery strategies for CVRM indications.
- Develop and execute an overarching biological strategy to identify, prioritize, and validate cell-surface receptors capable of mediating selective nucleic acid delivery to CVRM-relevant tissues.
- Establish, culture, and...
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