Genentech discovers, develops, manufactures and commercializes treatments for patients with serious and life-threatening medical conditions. Backed by North Carolina Biotechnology Center.
About the role
As a Scientist II in the Small Molecule Biomarkers (Metabolomics & Lipidomics) team within our Drug Metabolism and Pharmacokinetics (DMPK) department, you will play a key role in advancing safe and effective therapeutics for patients. Joining Genentech Research and Early Development (gRED), you will empower drug discovery across the organization by executing high-throughput mass spectrometry workflows and applying modern tools—including Generative AI—to drive biological insights. Found on 1752vc Careers, the job board for startup and VC roles.
What they're looking for
- Experimental Execution: Routinely perform onsite lab-based LC-MS workflow methods to acquire high-quality mass spectrometry biomarker data supporting target biology evaluation, drug discovery and development
- Data & AI Workflows: Execute mass spectrometry data processing and statistical analysis leveraging in-house AI/ML workflows and commercial software tools to scale analysis and reporting
- Support routine lab operations including instrument maintenance, consumable and chemical management, and compliance with lab safety and quality standards
- Technical Mastery: Practical experience operating and troubleshooting modern LC-MS platforms (e.g., UHPLC, triple quadrupole, high-resolution mass spectrometers) and using analytical data processing software
- Metabolic & Computational Insight: Solid foundation in biochemistry, cellular metabolism, coupled with hands-on experience or strong aptitude using Generative AI tools for coding
- Collaboration & Communication: Excellent communication skills with a proven track record of working effectively in multidisciplinary project teams
More about this role
The Opportunity
As a Scientist II in the Small Molecule Biomarkers (Metabolomics & Lipidomics) team within our Drug Metabolism and Pharmacokinetics (DMPK) department, you will play a key role in advancing safe and effective therapeutics for patients. Joining Genentech Research and Early Development (gRED), you will empower drug discovery across the organization by executing high-throughput mass spectrometry workflows and applying modern tools—including Generative AI—to drive biological insights.
This position is based in South San Francisco, on site .
Key Responsibilities
- Experimental Execution: Routinely perform onsite lab-based LC-MS workflow methods to acquire high-quality mass spectrometry biomarker data supporting target biology evaluation, drug discovery and development.
- Automation: Use liquid handling automation to execute automated sample preparation workflows, including protein precipitation, liquid-liquid and solid-phase extraction, and chemical derivatization. Prepare and execute global and targeted metabolomics and lipidomics protocols across diverse biological specimens, including biofluids, tissues, and cells.
- Data & AI Workflows: Execute mass spectrometry data...
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