Glyphic Biotechnologies is a biotechnology company that develops a protein sequencing platform. While DNA can reveal biological insights, proteins provide the actual insights into the functions of our bodies. Backed by MedTech Innovator.
About the role
Glyphic is seeking a Scientist or Senior Scientist to lead research on the library preparation stage of our single-molecule protein sequencing platform. Reporting to the Director of Assay Development, you will own how DNA molecules produced by our protein sequencing assay (ProSE) are prepared for and read on the nanopore, the last steps of the assay through library prep to sequencing. ProSE outputs are not standard sequencing templates and they impose constraints that off-the-shelf kits don’t address. Found on 1752vc Careers, the job board for startup and VC roles.
What they're looking for
- PhD in Molecular Biology, Biochemistry, Bioengineering, Chemical Biology, or a related field, with 1+ years of industry experience. Alternatively, an MS with 5+ years of relevant experience
- Deep understanding of enzymatic DNA manipulation (ligation, end repair, phosphorylation, polymerase extension, and adapter attachment), including how the enzymes involved actually work
- Experience working with chemically modified DNA or RNA, and troubleshooting nucleic acid secondary structure and its effect on reaction or sequencing performance
- End-to-end systems thinking: the ability to reason about how upstream chemistry, construct design, and sequencing hardware each contribute to a result, and to design experiments that separate them
- Demonstrated ability to reason from first principles to predict reagent and condition efficacy, rather than relying solely on empirical screening
- Proficiency with DNA characterization and QC methods such as capillary or gel electrophoresis
More about this role
At Glyphic Biotechnologies, we plan to create the protein revolution for which scientists and researchers have been waiting. We are developing a massively parallel, single-molecule proteome sequencing platform that will transform life science discovery and usher in a new era of insights into human biology and disease. To date, we have raised >$80M from venture partners and non-dilutive grant funding to achieve our vision of next generation proteome sequencing.
Glyphic is seeking a Scientist or Senior Scientist to lead research on the library preparation stage of our single-molecule protein sequencing platform. Reporting to the Director of Assay Development, you will own how DNA molecules produced by our protein sequencing assay (ProSE) are prepared for and read on the nanopore, the last steps of the assay through library prep to sequencing. ProSE outputs are not standard sequencing templates and they impose constraints that off-the-shelf kits don’t address. As a successful scientist in this role, you will design creatively around those constraints and turn one-off gains in accuracy and read count into results the team can reproduce run after run.
The ideal candidate thinks about...
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