Are you ready to turn novel, in vivo-validated targets into small molecule drug programs — building the assays, screening cascades and human-relevant models that decide which chemistry moves forward? Gordian is the leader in applying in vivo screening for... Backed by Stanford.
About the role
Your mission is to make three things work across our obesity, kidney (CKD/DKD) and heart failure (HFpEF) programs: Found on 1752vc Careers, the job board for startup and VC roles.
What they're looking for
- Experience across more than one of kidney, cardiac and metabolic biology
- Target engagement and biophysical methods such as CETSA, NanoBRET or SPR
- First-in-class target experience, with no prior chemistry or tool compounds
- Lab automation, liquid handling or high-content imaging
- Advanced human cell models: iPSC-derived cells, 3D cultures or organoids, engineered heart tissue, kidney organoids or microphysiological systems
- Understanding of PK/PD and in vitro to in vivo translation in cardio-renal disease
More about this role
Your mission is to make three things work across our obesity, kidney (CKD/DKD) and heart failure (HFpEF) programs:
- Assays for novel targets. Most of our targets have no tool compounds, no off-the-shelf assay and incomplete pathway biology. You will design, develop and validate the biochemical, biophysical and cell-based assays that let us find and optimize chemical matter against them.
- The screening cascade. Through working with our medicinal chemists, you will design the cascade from hit identification through lead optimization — primary, orthogonal, counter-screen, selectivity, functional and mechanism of action — set progression criteria and keep data flowing on a 1-2 week cadence that drives design-make-test cycles.
- Mechanism in human systems. Through working with our ex vivo team, you will support to identify and develop disease-relevant human models, define target engagement, mechanism of action and efficacy readouts, and benchmark against standard-of-care drugs where it matters.
You will direct external work as well as your own: scoping, selecting and managing CROs for screening, transferring assays with bridging studies, and making sure every external number meets...
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