Dedicated to oncology, women’s health, and organ health. Natera’s cell-free DNA tests help protect health and inform more personalized decisions about care. Backed by Lightspeed and Sequoia.
About the role
Natera is seeking a highly motivated Scientist, R&D – Immunohistochemistry (IHC) & Histology to join the Oncology Product Development team. This role will focus on the development, optimization, verification, and validation of IHC and tissue-based workflows supporting oncology products and clinical assay development. Found on 1752vc Careers, the job board for startup and VC roles.
What they're looking for
- Strong hands-on expertise in IHC assay development, optimization, and troubleshooting, with solid knowledge of histology and FFPE tissue workflows
- Experience with antibody characterization/titration, antigen retrieval, staining optimization, controls, tissue morphology, and assay performance evaluation
- Experience with automated IHC/ISH platforms is highly preferred, hands-on experience with the Roche BenchMark ULTRA IHC/ISH System is a strong plus
- Experience with H&E staining, microtomy/tissue sectioning, microscopy, digital pathology, or image analysis is desirable
- NGS and molecular biology experience is a plus, particularly with FFPE nucleic acid extraction, PCR/qPCR, NGS library preparation, or hybrid capture workflows
- Experience with assay development and validation in a regulated clinical laboratory, molecular diagnostics, or LDT environment is preferred
More about this role
Natera is seeking a highly motivated Scientist, R&D – Immunohistochemistry (IHC) & Histology to join the Oncology Product Development team. This role will focus on the development, optimization, verification, and validation of IHC and tissue-based workflows supporting oncology products and clinical assay development.
The ideal candidate will have strong hands-on experience in IHC assay development and optimization, supported by a solid foundation in histology and FFPE tissue workflows. Experience with automated IHC/ISH staining platforms, particularly the Roche BenchMark ULTRA IHC/ISH System, is highly desirable. Experience with NGS and molecular biology workflows is an additional plus.
- Design and execute development, optimization, verification, and validation studies for IHC, histology, and tissue-based workflows.
- Develop and optimize IHC assays, including antibody selection and titration, antigen retrieval, staining conditions, controls, and assay performance assessment.
- Evaluate and optimize histology and pre-analytical variables, including tissue fixation, FFPE processing, embedding, sectioning, H&E staining, and slide preparation.
- Develop and troubleshoot workflows on...
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