NewLimit is extending human healthspan by unlocking regenerative potential. Backed by Kleiner Perkins.
About the role
This is a hands-on bench role with targeting compositional and reaction design ownership. You will work closely with the Delivery Sciences and biology teams to design and build relevant targeting lipids portfolio for New Limit’s pipeline programs. Found on 1752vc Careers, the job board for startup and VC roles.
What they're looking for
- Strong skill set in the design formulation of new targeted LNPs, performed personally rather than with a supervisor directing each step
- SAR-driven design, purification, and characterization of tLNPs and targeted moiety conjugated lipids and AI-based SAR prediction tools for tLNP applications
- Practical purification skills spanning normal- and reverse-phase, size-exclusion chromatography and preparative HPLC
- Analytical characterization across LC-CAD, LC-UV, DLS, CE, bio-layer interferometry and surface plasmon resonance with the ability to deconvolute the data to produce well-characterized tLNPs
More about this role
NewLimit is a biotechnology company working to radically extend human healthspan. We’re developing medicines to treat aging by reprogramming the epigenome, a new therapeutic mechanism to restore youthful function in aged cells. We’ve built the world’s leading experimental and artificial intelligence system to discover reprogramming medicines at massive scale. Our first products are focused on restoring youthful metabolic, endothelial, and immune function.
NewLimit is seeking a Scientist to design, formulate and characterize targeted LNPs (tLNPs) with antibody conjugates, Nanobodies, and scFv’s to build our targeting LNP platform with a particular focus on getting nucleic acid payloads into target cells and tissues beyond the liver.
This is a hands-on bench role with targeting compositional and reaction design ownership. You will work closely with the Delivery Sciences and biology teams to design and build relevant targeting lipids portfolio for New Limit’s pipeline programs.
- Design and develop LNP compositions and conjugation chemistries for antibodies, nanobodies, scFv’s, peptides, and other targeting moieties across multiple structural families, pushing the platform beyond...
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