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About the role
Nurix Therapeutics is seeking a Head of Investigative Toxicology to establish and lead our in-house in vitro toxicology testing capability. Reporting into the Preclinical Toxicology leadership team, this individual will build the assays, infrastructure, and mechanistic understanding needed to characterize target- and modality-related safety liabilities earlier in discovery, reducing reliance on external CROs for early screening and de-risking. Found on 1752vc Careers, the job board for startup and VC roles.
What they're looking for
- Design, establish, and validate an in-house in vitro toxicology testing platform, including assay selection, equipment procurement, protocol development, and standard operating procedures
- Develop and implement in vitro toxicology (primary and immortalized cell culture, hepatocyte and iPSC cardiomyocyte models) assays to screen for cytotoxicity and off-target liabilities
- Define the technical roadmap and prioritize which in vitro assays to bring in-house versus continue to source through CRO partners, balancing scientific value, cost, and speed
- Own day-to-day lab operations for the function, including equipment maintenance, vendor and reagent management, and data management systems
- Serve as the in vitro/investigative toxicology representative on discovery project teams, providing mechanistic insight into target and modality-related safety findings
- Design and interpret investigative studies to elucidate mechanisms of toxicity, including neosubstrate and off-target degradation risk relevant to targeted protein degrader molecules
More about this role
Build Nurix’s in-house in vitro toxicology capability from the ground up. As Director, Head of Investigative Toxicology, you’ll establish the assays, infrastructure and mechanistic understanding to identify target- and modality-related safety liabilities earlier in discovery, shaping lead selection for our growing pipeline of targeted protein degrader programs. This is a hands-on, lab-based leadership role.
Nurix Therapeutics is seeking a Head of Investigative Toxicology to establish and lead our in-house in vitro toxicology testing capability. Reporting into the Preclinical Toxicology leadership team, this individual will build the assays, infrastructure, and mechanistic understanding needed to characterize target- and modality-related safety liabilities earlier in discovery, reducing reliance on external CROs for early screening and de-risking. This is a hands-on, lab-based leadership role for a scientist who wants to build a function from the ground up, working in close partnership with Discovery Biology, Chemistry, DMPK, and Pharmacology to inform lead selection and optimization for our growing pipeline of targeted protein degrader programs. The position reports to the Senior...
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