Pliant Therapeutics Inc. is a clinical-stage biopharmaceutical company focused on discovering and developing novel therapies for the treatment of fibrosis and related diseases. Backed by Menlo Ventures.
About the role
At Pliant, we believe differentiated science can make a meaningful impact. We see our success as a direct result of the central role that each team member plays in advancing our mission to develop therapies that target the disease at its source. We are seeking creative, curious and collaborative individuals who dare to succeed , are committed to making an important impact on patient’s lives and will help us build one Pliant ! Found on 1752vc Careers, the job board for startup and VC roles.
What they're looking for
- BS in Biochemistry, Biology, Chemistry or a related field with 7+ years of relevant biopharmaceutical industry experience, or an MS with 5+ years
- Direct, hands-on experience developing and running AlphaScreen and/or AlphaLISA assays, including troubleshooting signal window, hook effect and compound interference
- Demonstrated track record of developing and validating biochemical binding assays for medium- to high-throughput screening in 384- and/or 1536-well formats
- Proficiency with liquid handlers and plate-based workflows (e.g., i5 BIOMEK, Tempest or similar) and multimode plate readers capable of Alpha detection (e.g., EnVision, PHERAstar)
- Familiarity with high-content imaging equipment such as the Operetta CLS
- Sound understanding of binding kinetics and pharmacology: Kd, Ki, IC50, Cheng–Prusoff, and the assumptions behind them
More about this role
At Pliant, we believe differentiated science can make a meaningful impact. We see our success as a direct result of the central role that each team member plays in advancing our mission to develop therapies that target the disease at its source. We are seeking creative, curious and collaborative individuals who dare to succeed , are committed to making an important impact on patient’s lives and will help us build one Pliant !
We are seeking an Associate Scientist I to develop, optimize and run biochemical binding assays that screen compounds in medium- to high-throughput format. You will own AlphaScreen/AlphaLISA assays from reagent qualification through routine screening, generating the potency and selectivity data that drive our medicinal chemistry decisions. This is a hands-on laboratory role reporting to Senior Vice President, Research based in South San Francisco.
- Design, develop and optimize biochemical binding assays, with a focus on AlphaScreen/AlphaLISA proximity formats (e.g., protein–protein and protein–ligand interaction and competition assays).
- Optimize assay conditions — bead and reagent titrations, cross-titration of binding partners, buffer, DMSO tolerance,...
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