Difficult protein production made simple. A next-generation expression system for next-generation therapeutics. Backed by SOSV.
About the role
Prolific Machines is ushering in a new era of biotechnology with light. Our first-of-its-kind optogenetic platform delivers unprecedented control, precisely guiding cellular behavior when and where it matters most. Unlike existing tools used to control biology, our technology enables dynamic, tunable control over virtually any cellular function in any cell type. Found on 1752vc Careers, the job board for startup and VC roles.
What they're looking for
- Hold a PhD in Analytical Chemistry, Biochemistry, Chemistry, Pharmaceutical Sciences, or a related field with 5+ years of biologics industry experience, or an MS/BS with equivalent relevant industry experience
- Have a track record of measurably improving the throughput, turnaround, or robustness of analytical workflows in a high-volume setting
- Have deep hands-on expertise in chromatographic and electrophoretic methods for biologics (e.g., Protein A, SEC, RP, IEX, CE-SDS, icIEF), including troubleshooting
- Have hands-on LC-MS experience for protein characterization (intact and subunit mass, peptide mapping, PTM and glycan analysis) and with MS data processing software
- Have led the characterization of a biologic for a project team: designing studies, interpreting complex or conflicting data, and making a clear recommendation
- Bring statistical thinking to experimental design and interpretation
More about this role
Prolific Machines is ushering in a new era of biotechnology with light. Our first-of-its-kind optogenetic platform delivers unprecedented control, precisely guiding cellular behavior when and where it matters most. Unlike existing tools used to control biology, our technology enables dynamic, tunable control over virtually any cellular function in any cell type. We're enabling partners to unlock robust efficiency, quality, and reproducibility advantages across the most complex pharmaceuticals and therapeutic proteins. Prolific is supported by leading investors, including Bill Gates’s Breakthrough Energy Ventures, Mayfield and SOSV.
The Analytical Chemistry team is looking for a Senior Scientist who will execute and improve the efficiency of core analytical procedures including titer determination and product quality assessment (Aggregation, charge heterogeneity, glycan composition). Additionally this scientist will design and execute characterizations supporting cell line development and bioprocess development programs. This position will balance hands-on lab work, coordinating resourcing within the team and people management.
- Manage day to day execution of core platform assays...
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