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Research Associate II, mRNA Technologies

Repertoire Immune Medicines · Remote (US) · Remote

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About Repertoire Immune Medicines

Repertoire Immune Medicines is a clinical-stage biotechnology company working to unlock and direct the remarkable power of the human immune system to prevent or treat cancer, as well as autoimmune and infectious disease. Backed by SoftBank VF.

About the role

We are seeking a motivated Research Associate II to join our Integrated Therapeutic Engineering and Design (ITED) team and help advance the development of cutting edge mRNA-LNP work in autoimmunity and cancer vaccines . In this lab-based role, you will play a key part in design and production of immune-silent mRNAs that deliver disease-modifying epitopes and immunomodulators to target multiple autoimmune disorders . Found on 1752vc Careers, the job board for startup and VC roles.

What they're looking for

  • Design and execute experiments as a key contributor to the ITED team, under the supervision of your manager and scientific project leads
  • Manage large-scale productions of high quality in vitro transcribed mRNA, including purification and QC assessments with documentation
  • Assess the production of various protein products from the mRNAs produced, using techniques such as ELISAs, western blots and flow cytometry
  • Cross-train with the LNP team to learn complete mRNA-LNP encapsulation techniques
  • Maintain good laboratory practices, including accurate ELN documentation, instrument and reagent validation, and adherence to lab safety policies
  • Present data and analysis at cross-disciplinary team meetings and build working relationships that move projects forward
More about this role

Repertoire Immune Medicines is a clinical-stage biotechnology company working to unlock and direct the remarkable power of the human immune system to prevent or treat cancer, as well as resetting the immune system to treat autoimmune disorders. The company is founded on the belief that the repertoire of T cell receptor (TCR)-antigen codes that drive health and disease represents one of the greatest opportunities for innovation in medical science. Repertoire scientists created and developed the DECODE suite of technologies, which allow in-depth characterization of TCR-antigen pairs, and the ability to rationally design and develop novel targeted immune medicines.

From its sites in Watertown, Massachusetts, and Zurich, Switzerland, Repertoire’s team of more than 80 is creating a new category of immune medicines enabled from its DECODE discovery platform. Repertoire is currently using its proprietary platform to discover novel epitopes and TCRs from patients with autoimmune diseases such as type 1 diabetes and multiple sclerosis as well as to enable development of immune oncology based therapeutics to treat solid tumors.

Repertoire was founded in 2019 by Flagship Pioneering and is...

Read the full posting on Repertoire Immune Medicines's site ↗

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