Repertoire Immune Medicines is a clinical-stage biotechnology company working to unlock and direct the remarkable power of the human immune system to prevent or treat cancer, as well as autoimmune and infectious disease. Backed by SoftBank VF.
About the role
We are seeking a highly skilled and motivated Scientist II to join Repertoire’s autoimmune tolerance induction team. Working with a dedicated team of scientists and research associates, you will help advance Repertoire’s novel immune tolerance modality across multiple indications. Found on 1752vc Careers, the job board for startup and VC roles.
What they're looking for
- Design and optimize the molecular components of mRNA molecules for antigen expression and presentation in immune cells, as well as in other tissue targets for systemic protein delivery
- Collaborate with preclinical biology and disease area teams on characterizing construct designs and payloads for functional activity across in vitro and in vivo models
- Establish, optimize, and innovate processes for scalable in vitro transcription (IVT) production and purification of mRNA for discovery and therapeutic applications
- Contribute to the development of analytical characterization methods for mRNA molecules and mRNA-LNP drug product with an eye toward tech transfer to a CRO/CDMO
- Ensure supply of in vivo grade mRNA and mRNA-LNP product to the tolerance team and throughout Repertoire
- Design and maintain the external supply chain for research grade plasmids for IVT production of mRNA
More about this role
Repertoire Immune Medicines is a clinical-stage biotechnology company harnessing the power of the human immune system to develop transformative therapies for cancer and autoimmune disease. Using its proprietary DECODE TM platform—which maps the immune synapse between T cell receptors (TCRs) and their antigen targets—Repertoire translates unique biological insights into potent and targeted off-the-shelf immune medicines. The company integrates deep protein engineering expertise with artificial intelligence, powered by a proprietary DECODE database of over one billion TCR-antigen interactions, to accelerate discovery and optimize drug candidates.
From its sites in Watertown, Massachusetts and Zurich, Switzerland, Repertoire is advancing a pipeline of T cell-targeted immunotherapies with the potential to address a broad range of cancers and autoimmune disorders. The company’s lead oncology program, RPTR-1-201, a TCR bispecific, has initiated a Phase 1/2 clinical trial across multiple solid tumor indications. Repertoire plans to advance additional TCR bispecific therapies into clinical trials over the next 12-18 months. In autoimmune disease, Repertoire is partnering with leading...
Read the full posting on Repertoire Immune Medicines's site ↗
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