Backed by GV.
About the role
We are seeking a Senior Director, Head of Structural Biology, to lead the scientific strategy, team development, and operations of our Structural Biology group. The group integrates X-ray crystallography, NMR, and cryo-EM to advance oncology drug discovery through Revolution Medicines’ tri-complex molecular glue platform. Found on 1752vc Careers, the job board for startup and VC roles.
What they're looking for
- PhD in structural biology, biophysics, biochemistry, or a related discipline, with 12+ years biotechnology or pharmaceutical industry experience and a demonstrated record of scientific and people leadership
- Proven ability to lead a structural biology group, develop scientific leaders, and translate research strategy into priorities, resource plans, and measurable outcomes across multiple discovery programs
- Deep expertise in at least one of X-ray crystallography, NMR, or cryo-EM, with sufficient breadth across all three to guide specialists, evaluate data critically, and develop an integrated experimental strategy
- Strong track record of applying structural biology to small molecule drug discovery in close partnership with medicinal chemistry, including translating structural findings into compound design and optimization decisions
- Expertise in protein-ligand and protein-protein interactions, complex assembly, and structure-function analysis, with the ability to integrate structural, biophysical, biochemical, and cellular evidence into testable mechanistic models
- Experience integrating structural methods with computational modeling, molecular simulation, or complementary biophysical approaches to explain molecular recognition and dynamics
More about this role
Revolution Medicines is a global, commercial-state oncology company dedicated to discovering, developing and delivering innovative medicines for patients with RAS-addicted cancers. Leveraging its differentiated RAS(ON) tri-complex inhibitor platform, the company is advancing a broad, integrated portfolio of oral RAS(ON) inhibitors designed to directly target the active, cancer-driving state of RAS. Founded on rigorous scientific inquiry and a willingness to challenge long-held assumptions, Revolution Medicines is committed to changing the trajectory of disease for patients with RAS-addicted cancers worldwide.
Our people are united by a shared way of working: follow the science, challenge assumptions, act with urgency and hold ourselves to a high standard of rigor—all in service of patients.
We are seeking a Senior Director, Head of Structural Biology, to lead the scientific strategy, team development, and operations of our Structural Biology group. The group integrates X-ray crystallography, NMR, and cryo-EM to advance oncology drug discovery through Revolution Medicines’ tri-complex molecular glue platform. You will partner closely with medicinal and computational chemistry to...
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